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| Parahym,Ana Maria Rabelo de Carvalho; Rolim Neto,Pedro José; Silva,Carolina Maria da; Domingos,Igor de Farias; Gonçalves,Sarah Santos; Leite,Edinalva Pereira; Morais,Vera Lúcia Lins de; Macêdo,Danielle Patrícia Cerqueira; Lima Neto,Reginaldo Gonçalves de; Neves,Rejane Pereira. |
| We report a case of invasive infection due to Saprochaete capitata in a patient with hematological malignancies after chemotherapy treatment and empiric antifungal therapy with caspofungin. Although severely immunocompromised the patient survived been treated with amphotericin B lipid complex associated with voriconazole. |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Invasive infection; Saprochaete capitata; Geotrichum capitatum; Hematological malignancies; Antifungal susceptibility. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000200527 |
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| Vitiello,Glauco Akelinghton Freire; Guembarovski,Roberta Losi; Oliveira,Carlos Eduardo Coral de; Amarante,Marla Karine; Perim,Aparecida de Lourdes; Watanabe,Maria Angelica Ehara. |
| Hematological malignancies (HM) are a group of neoplastic diseases that arise from hematologic cell lineages. Transforming growth factor beta 1 (TGFβ1) is shown to negatively regulate normal and malignant hematopoiesis and, in immunological context, to promote T cell exhaustion and generation of regulatory T cells, which are shown to be deleterious in cancer, by the induction of transcription factor FOXP3 expression. The present study aimed to evaluate TGFB1 exon-1 rs1800470 and FOXP3 intron-1 rs2232365 polymorphisms in relation to HM susceptibility. DNA was extracted from blood samples of 43 HM patients and 142 neoplasia-free individuals and polymorphisms were analyzed by allelic-specific PCR. Association analysis was assessed by the Odds Ratio (OR) with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hematological malignancies; TGFB1; FOXP3; Genetic polymorphism; Susceptibility. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400553 |
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